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Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808
- Chien, David T;
- Szardenings, A Katrin;
- Bahri, Shadfar;
- Walsh, Joseph C;
- Mu, Fanrong;
- Xia, Chunfang;
- Shankle, William R;
- Lerner, Alan J;
- Su, Min-Ying;
- Elizarov, Arkadij;
- Kolb, Hartmuth C
Published Web Location
https://doi.org/10.3233/jad-130098Abstract
Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have recently reported early clinical results of a novel PHF-tau targeting PET imaging agent, [F18]-T807. Since then, we have investigated a second novel PHF-tau targeting PET imaging agent, [F18]-T808, with different pharmacokinetic characteristics, which may be favorable for imaging Alzheimer's disease and other tauopathies. Here, we describe the first human brain images with [F18]-T808.
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