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Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis
- Komatsu, Noriko;
- Okamoto, Kazuo;
- Sawa, Shinichiro;
- Nakashima, Tomoki;
- Oh-hora, Masatsugu;
- Kodama, Tatsuhiko;
- Tanaka, Sakae;
- Bluestone, Jeffrey A;
- Takayanagi, Hiroshi
Published Web Location
https://doi.org/10.1038/nm.3432Abstract
Regulatory T (Treg) cells exhibit substantial phenotypic and functional plasticity. Hiroshi Takayanagi and his colleagues report that in autoimmune arthritis, a subset of Treg cells can lose Foxp3 expression and convert into TH17 cells. This conversion is mediated by synovial fibroblast-derived IL-6, and in vivo, these cells are osteoclastogenic and exacerbate arthritis. These findings suggest that a proportion of pathogenic TH17 cells in autoimmune disease may be derived from Treg cells.
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