- Main
Animal models of obesity and diabetes mellitus
- Kleinert, Maximilian;
- Clemmensen, Christoffer;
- Hofmann, Susanna M;
- Moore, Mary C;
- Renner, Simone;
- Woods, Stephen C;
- Huypens, Peter;
- Beckers, Johannes;
- de Angelis, Martin Hrabe;
- Schürmann, Annette;
- Bakhti, Mostafa;
- Klingenspor, Martin;
- Heiman, Mark;
- Cherrington, Alan D;
- Ristow, Michael;
- Lickert, Heiko;
- Wolf, Eckhard;
- Havel, Peter J;
- Müller, Timo D;
- Tschöp, Matthias H
Published Web Location
https://doi.org/10.1038/nrendo.2017.161Abstract
Key PointsDevelopment of safe and potent therapeutics is required to combat the obesity and diabetes mellitus pandemicAnimal models remain indispensable for discovering, validating and optimizing novel therapeutics for their safe use in humansTo improve the transition from bench to bedside, researchers must select the appropriate models, beware a myriad of confounding factors and draw appropriate conclusionsExperimental procedures and conditions should be accurately detailed to improve the reproducibility and translation of findings in preclinical animal modelsDifferent animal models, ranging from non-mammalian models to non-human primates, each have distinct advantages and limitations
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