UCSF

The noninvasive detection of myeloperoxidase (MPO)-mediated oxidative stress in deep tissue inflammatory foci has been hampered by poor penetration of luminol-emitted short wavelength light due to tissue absorption and scattering. To circumvent this, Daniel Ansaldi and his colleagues have adopted a chemiluminescence resonance energy transfer approach whereby near-infrared (NIR) nanoparticles are used to red-shift luminol-emitted blue light to the NIR. Improved in vivo detectability of MPO is demonstrated in a lipopolysaccharide-induced pulmonary inflammation model, as well as in deep tissue tumor metastases.