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Exploring the repeat protein universe through computational protein design
- Brunette, TJ;
- Parmeggiani, Fabio;
- Huang, Po-Ssu;
- Bhabha, Gira;
- Ekiert, Damian C;
- Tsutakawa, Susan E;
- Hura, Greg L;
- Tainer, John A;
- Baker, David
Published Web Location
https://doi.org/10.1038/nature16162Abstract
In this study, 83 proteins containing helix–loop–helix–loop repeats were designed—with sequences unrelated to known repeat proteins—and experimentally characterized; 43 solution X-ray scattering spectra and 15 structures of the designed proteins show that these non-natural repeat proteins have a broad range of curvatures and that their overall structures are in close agreement with design models.
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