- De Leon, Jessica;
- Mandelli, Maria Luisa;
- Nolan, Amber;
- Miller, Zachary A;
- Mead, Christie;
- Watson, Christa;
- Welch, Ariane E;
- Henry, Maya L;
- Bourakova, Viktoriya;
- La Joie, Renaud;
- Bajorek, Lynn P;
- Grinberg, Lea;
- Rabinovici, Gil;
- Miller, Bruce L;
- Gorno-Tempini, Maria Luisa
A 66-year-old woman presented with agrammatism and apraxia of speech, meeting criteria for non-fluent/agrammatic variant primary progressive aphasia (nfvPPA). However, three years later, she developed frontal/executive, short-term phonological memory, visuospatial, and visual memory deficits suggesting involvement of multiple brain networks. Multimodal neuroimaging showed damage of both fronto-striatal and posterior brain regions. She was found to have multiple pathological processes: corticobasal degeneration (CBD), Alzheimer's disease (AD), and TAR DNA-binding protein (TDP)-43 type A. We hypothesize that cognitive and neuroimaging findings consistent with damage to multiple brain networks, each associated with vulnerability to certain molecular disease subtypes, could indicate mixed pathology.