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Single-base DNA discrimination via transverse ionic transport
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https://doi.org/10.1088/0957-4484/24/41/415101Abstract
We suggest the discrimination of single DNA bases via transverse ionic transport, namely by detecting the ionic current that flows in a channel while a single-stranded DNA is driven through an intersecting nanochannel. Our all-atom molecular dynamics simulations indeed show that the ionic currents of the four bases are statistically distinct, thus offering another possible approach to sequencing DNA.
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