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TRIMing Neural Connections with Ubiquitin
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https://doi.org/10.1016/j.devcel.2018.12.012Abstract
During evolution, ubiquitin ligases increased in number with increasing nervous system complexity. Recent work shows that proper brain development, cognitive ability, and social behavior in mice require the ubiquitin ligase TRIM67. The work illuminates how general regulators like ubiquitin promote specific functions such as nervous system wiring during development.
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