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An Old Drug for New Ideas: Metformin Promotes Adult Neurogenesis and Spatial Memory Formation
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https://doi.org/10.1016/j.stem.2012.06.003Abstract
Identifying well-tolerated, oral medications that enhance adult neurogenesis is of great clinical interest. In this issue of Cell Stem Cell, Wang et al. (2012) demonstrate that the diabetes medication metformin enhances spatial learning in mice by activating the atypical PKC/CBP pathway in adult neural stem cells.
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