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snRNA Catalysts in the Spliceosome’s Ancient Core

Published Web Location

https://doi.org/10.1016/j.cell.2013.11.022
Abstract

The spliceosome, an assembly of snRNAs and proteins, catalyzes the removal of introns from premessenger RNAs. A new study identifies specific phosphates in the U2-U6 snRNA complex that position two catalytic metals. Remarkably, these correspond precisely to metal-binding phosphates in a homologous structure of Group II self-splicing introns, long proposed to be the ribozyme progenitor of spliceosome.

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