Skip to main content
eScholarship
Open Access Publications from the University of California
Refine Search

UCSF

UC San Francisco Previously Published Works bannerUCSF

Statistical approaches to accelerate the development of long-acting antiretrovirals for HIV pre-exposure prophylaxis.

Published Web Location

https://doi.org/10.1097/coh.0000000000000589
Abstract

Purpose of review

This review considers statistical issues in the design and analysis of the studies used to develop long-acting formulations of antiretrovirals for pre-exposure prophylaxis (PrEP).

Recent finding

An abundant pipeline of products is maturing. Accelerating their evaluation as clinical products requires abandonment of noninferiority standards. Randomized trials should be based on the comparison of principled but innovative estimates of background HIV risk and enrich enrollment for those who do not desire current PrEP products. At every stage of testing, innovative analyses can be applied to help inform and accelerate later studies.

Summary

The development of new long-acting PrEP regimens can be accelerated by innovations in design, ingenuity in synthesizing data sources, and application of causal inference methods.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View


Top