UCLA

The synthesis and modification of polypeptides from NCAs is described. Diblocks containing a hydrophilic segment of poly(Met) and a hydrophobic segment of rac-Leu were self-assembled into micelles. The poly(Met) was either oxidized to the sulfoxide or alkylated to the carboxymethylated sulfonium.

Additionally, a diblock containing poly(Met) and PEG was synthesized. The poly(Met) segment was alkylated with bromo methyl boronic acid, and the polymers bound covalently and reversibly to compounds that contain diol groups.