Boel, Judith A; de Bie, Rob MA; Schmand, Ben A; Dalrymple‐Alford, John C; Marras, Connie; Adler, Charles H; Goldman, Jennifer G; Tröster, Alexander I; Burn, David J; Litvan, Irene; Geurtsen, Gert J; Bernard, Bryan; Stebbins, Glenn; Filoteo, J Vincent; Weintraub, Daniel; Caviness, John N; Belden, Christine; Zabetian, Cyrus P; Cholerton, Brenna A; Huang, Xuemei; Eslinger, Paul J; Leverenz, James B; Duff‐Canning, Sarah; Farrer, Matt; Anderson, Tim J; Myall, Daniel J; Naismith, Sharon L; Lewis, Simon JG; Halliday, Glenda M; Wu, Ruey‐Meei; Williams‐Gray, Caroline H; Breen, David P; Barker, Roger A; Yarnall, Alison J; Klein, Martin; Mollenhauer, Brit; Trenkwalder, Claudia; Kulisevsky, Jaime; Pagonabarraga, Javier; Gasca‐Salas, Carmen; Rodriguez‐Oroz, Maria C; Junque, Carme; Segura, Barbara; Barone, Paolo; Santangelo, Gabriella; Cammisuli, Davide M; Biundo, Roberta; Antonini, Angelo; Weis, Luca; Pedersen, Kenn Freddy; Alves, Guido

doi:10.1002/mdc3.13451

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Level I PD‐MCI Using Global Cognitive Tests and the Risk for Parkinson's Disease Dementia

2022

Published Web Location

https://doi.org/10.1002/mdc3.13451

Abstract

Background

The criteria for PD-MCI allow the use of global cognitive tests. Their predictive value for conversion from PD-MCI to PDD, especially compared to comprehensive neuropsychological assessment, is unknown.

Methods

The MDS PD-MCI Study Group combined four datasets containing global cognitive tests as well as a comprehensive neuropsychological assessment to define PD-MCI (n = 467). Risk for developing PDD was examined using a Cox model. Global cognitive tests were compared to neuropsychological test batteries (Level I&II) in determining risk for PDD.

Results

PD-MCI based on a global cognitive test (MMSE or MoCA) increases the hazard for developing PDD (respectively HR = 2.57, P = 0.001; HR = 4.14, P = <0.001). The C-statistics for MMSE (0.72) and MoCA (0.70) were lower than those based on neuropsychological tests (Level I = 0.82; Level II = 0.81). Sensitivity, specificity and diagnostic accuracy balance was best in Level II.

Conclusion

MMSE and MoCA predict conversion to PDD. However, Level II neuropsychological assessment seems the preferred assessment for PD-MCI.

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