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Towards the Total Synthesis of A-74528

Abstract

Research progress towards the total synthesis of A-74528 is described herein. Highlights of the synthetic route include: efforts towards an elaborated β–tetralone which was used to probe the feasibility of a radical 6-endo cyclization to construct ring A of A-74528, a successful tandem [1,4]-Brook/Benzyne Diels-Alder to construct a key tricyclic intermediate, and work towards the current synthetic approach which utilizes novel conditions discovered in our lab to promote a semi-pinacol rearrangement.

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