UC Santa Cruz

Vibrio cholerae is an environmental pathogen that relies on biofilm formation for its infectivity.Here we investigate a genomic region that we suspect is involved in regulation of V. cholerae biofilm formation in response to environmental signals. The genomic region is particularly enriched in two component system proteins with domains that are able to degrade c-di-GMP. The genomic region spans from VC1080 to VC1087 in the V. cholerae genome and will be referred to as the VC1080 operon. This study provides information on the VC1080 to VC1087 gene products obtained by various bioinformatic analysis and presents results from the initial studies investigating the influence of each gene on V. cholerae biofilm formation and motility.