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Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases

Published Web Location

https://doi.org/10.2147/dmso.s159315
Abstract

Background

Follistatin (Fst) promotes brown adipocyte characteristics in adipose tissues.

Methods

Abdominal fat volume (CT scan), glucose clearance (GTT test), and metabolomics analysis (mass spectrometry) of adipose tissues from Fst transgenic (Fst-Tg) and wild type (WT) control mice were analyzed. Oxygen consumption (Seahorse Analyzer) and lipidomics (gas chromatography) was analyzed in 3T3-L1 cells.

Results

Fst-Tg mice show significant decrease in abdominal fat content, increased glucose clearance, improved plasma lipid profiles and significant changes in several conventional metabolites compared to the WT mice. Furthermore, overexpression of Fst in 3T3-L1 cells resulted in up regulation of key brown/beige markers and changes in lipidomics profiles.

Conclusion

Fst modulates key factors involved in promoting metabolic syndrome and could be used for therapeutic intervention.

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