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Polo-like Kinase 4 Inhibition: A Strategy for Cancer Therapy?
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https://doi.org/10.1016/j.ccr.2014.07.017Abstract
In this issue of Cancer Cell, Mason and colleagues describe the development of a Polo-like kinase 4 (PLK4) inhibitor (CFI-400945), with promising activity against tumors formed in mice from patient-derived tumor tissue. A clinical trial has been initiated, but questions remain as to whether PLK4 is the only relevant therapeutic target.
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