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Fueling Up Skeletal Muscle to Reduce Obesity: A TrkB Story
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https://doi.org/10.1016/j.chembiol.2015.03.004Abstract
Targeting TrkB signaling could represent a good therapeutic strategy to prevent obesity. In this issue of Chemistry & Biology, Chan et al. report the efficacy of 7,8-DHT, a TrkB agonist, in preventing obesity in female mice. The underlying molecular mechanisms behind this activity seem to involve increased energy expenditure in skeletal muscle.
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