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Effects of ErB Ligand Treatment on Purkinje Neuron Dysfunction in an EAE Mouse Model
- Ogundare, Oluwadara
- Advisor(s): Tiwari-Woodruff, Seema
Abstract
Multiple sclerosis is a chronic demyelinating disease of the central nervous system. Patients with Ms. See a range of symptoms including cognitive dysfunction, vision problems, as well as symptoms of cerebellar ataxia. Previous studies have shown both Purkinje cell and mitochondrial dysfunction due to the demyelination seen in multiple sclerosis. This study aims to analyze the direct or indirect effect of an estrogen receptor beta ligand and usual chloride O methyl. Unfortunately, due to poor tissue quality, the results from this study are inconclusive and must be repeated. Regardless this study creates a basis of information for further research to expand upon.
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