UCSF

γ oscillations, which can be identified by rhythmic electrical signals ∼30-100 Hz, consist of interactions between excitatory and inhibitory neurons that result in rhythmic inhibition capable of entraining firing within local cortical circuits. Many possible mechanisms have been described through which γ oscillations could act on cortical circuits to modulate their responses to input, alter their patterns of activity, and/or enhance the efficacy of their outputs onto downstream targets. Recently, several studies have observed changes in behavior after optogenetically manipulating neocortical γ oscillations. Now, future studies should determine whether these manipulations elicit physiological correlates associated with specific mechanisms through which γ oscillations are hypothesized to modulate cortical circuit function. There are numerous such mechanisms, so identifying which ones are actually engaged by optogenetic manipulations known to affect behavior would help flesh out exactly how γ oscillations contribute to cortical circuit function under normal and/or pathological conditions.