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c-Raf in KRas Mutant Cancers: A Moving Target
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https://doi.org/10.1016/j.ccell.2018.01.017Abstract
Therapies for KRas cancers remain a major clinical need. In the current issue of Cancer Cell, Sanclemente and coworkers in Mariano Barbacid's group validate c-Raf as a prime target for these cancers. c-Raf ablation caused regression of advanced KRasG12V/Trp53 tumors, without obvious systemic toxicity and without affecting MAPK signaling.
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