UCLA

Adolescents and young adults (AYAs) undergoing allogeneic hematopoietic stem cell transplantation (HSCT) have unique risk factors and poor outcomes when compared to children, but this population has not been well-studied. We sought to examine the prevalence of various risk factors in AYAs undergoing allogeneic HSCT and determine which factors had the greatest impact on overall survival (OS) and non-relapse mortality. This was accomplished by retrospectively collecting data on 241 patients who received their first allogeneic HSCT at UCLA between 2005-2015. Few of the comorbidities included in the hematopoietic stem cell transplantation – comorbidity index (HCT-CI) were prevalent in this population, with a history of pulmonary disease being most common. We demonstrated that compared to a baseline model, adding the HCT-CI did not improve the ability predict OS, while substituting just three important comorbidities including a history of pulmonary disease, infection, and prior malignancy resulted in a significant improvement in model performance.