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Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles
- Taunton, Jack;
- Serafimova, IM;
- Pufall, MA;
- Krishnan, S;
- Duda, K;
- Cohen, MS;
- Maglathlin, RL;
- McFarland, JM;
- Miller, RM;
- Frödin, M
Published Web Location
http://europepmc.org/articles/PMC3657615?pdf=renderNo data is associated with this publication.
Abstract
Targeting noncatalytic cysteine residues with irreversible acrylamide-based inhibitors is a powerful approach for enhancing pharmacological potency and selectivity. Nevertheless, concerns about off-target modification motivate the development of reversible
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