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Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins
- Costello, Joseph;
- Maeder, ML;
- Angstman, JF;
- Richardson, ME;
- Linder, SJ;
- Cascio, VM;
- Tsai, SQ;
- Ho, QH;
- Sander, JD;
- Reyon, D;
- Bernstein, BE
Published Web Location
http://europepmc.org/articles/PMC3858462?pdf=renderNo data is associated with this publication.
Abstract
Genome-wide studies have defined cell type-specific patterns of DNA methylation that are important for regulating gene expression in both normal development and disease. However, determining the functional significance of specific methylation events remain
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