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Covalent docking of large libraries for the discovery of chemical probes
- Shoichet, Brian;
- Taunton, Jack;
- London, N;
- Miller, RM;
- Krishnan, S;
- Uchida, K;
- Irwin, JJ;
- Eidam, O;
- Gibold, L;
- Cimermančič, P;
- Bonnet, R;
- Shoichet, BK
Published Web Location
http://europepmc.org/articles/PMC4232467?pdf=renderNo data is associated with this publication.
Abstract
Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies. Despite these advantages, protein-reactive compounds are usually avoided in high-throughput screening campaigns. He
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