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Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel
- Yang, Fan;
- Xiao, Xian;
- Cheng, Wei;
- Yang, Wei;
- Yu, Peilin;
- Song, Zhenzhen;
- Yarov-Yarovoy, Vladimir;
- Zheng, Jie
Published Web Location
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472570/No data is associated with this publication.
Abstract
A computational analysis of cryo-EM data defines the binding mode of capsaicin on TRPV1. A mutational analysis validates these findings, showing specific van der Waals and hydrogen-bonding interactions with the head, neck and tail regions of capsaicin.
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