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2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway
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https://doi.org/10.1016/j.bmcl.2014.09.001Abstract
Synthesis and SAR investigation of 2-guanidinoquinazolines, initially identified in a high content screen for selective STAT3 pathway inhibitors, led to a more potent analog (11c) that demonstrated improved anti-proliferative activity against a panel of HNSCC cell lines.
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