UC Irvine

Disorders of sex development (DSD) are congenital conditions in which chromosomal, gonadal, or anatomic sex development is atypical. Standard medical practice was to offer cosmetic genital surgery to DSD patients with genital ambiguity, however controversy persists surrounding early surgical intervention. This study reviews patients with DSD and ambiguous genitalia, in the ten years after the consensus meeting on disorders of sex development. A retrospective review of medical records from UCLA and UCI of children with DSD born between 2006-2016 was performed to determine if a decrease in surgery rates was associated with an increase in genetic testing. The eligible cohort of 167 patients was divided into 2 groups: patients born between 2006-2011 and patients born between 2012-2016. A significant decrease in surgery rate over time was observed, however there was not a significant increase in genetic testing over time. With a more robust evaluation of medical records, the observed trend of decrease in surgery and expected trend of increase in genetic testing is likely to be seen.