- Main
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
- Küpers, Leanne K;
- Monnereau, Claire;
- Sharp, Gemma C;
- Yousefi, Paul;
- Salas, Lucas A;
- Ghantous, Akram;
- Page, Christian M;
- Reese, Sarah E;
- Wilcox, Allen J;
- Czamara, Darina;
- Starling, Anne P;
- Novoloaca, Alexei;
- Lent, Samantha;
- Roy, Ritu;
- Hoyo, Cathrine;
- Breton, Carrie V;
- Allard, Catherine;
- Just, Allan C;
- Bakulski, Kelly M;
- Holloway, John W;
- Everson, Todd M;
- Xu, Cheng-Jian;
- Huang, Rae-Chi;
- van der Plaat, Diana A;
- Wielscher, Matthias;
- Merid, Simon Kebede;
- Ullemar, Vilhelmina;
- Rezwan, Faisal I;
- Lahti, Jari;
- van Dongen, Jenny;
- Langie, Sabine AS;
- Richardson, Tom G;
- Magnus, Maria C;
- Nohr, Ellen A;
- Xu, Zongli;
- Duijts, Liesbeth;
- Zhao, Shanshan;
- Zhang, Weiming;
- Plusquin, Michelle;
- DeMeo, Dawn L;
- Solomon, Olivia;
- Heimovaara, Joosje H;
- Jima, Dereje D;
- Gao, Lu;
- Bustamante, Mariona;
- Perron, Patrice;
- Wright, Robert O;
- Hertz-Picciotto, Irva;
- Zhang, Hongmei;
- Karagas, Margaret R;
- Gehring, Ulrike;
- Marsit, Carmen J;
- Beilin, Lawrence J;
- Vonk, Judith M;
- Jarvelin, Marjo-Riitta;
- Bergström, Anna;
- Örtqvist, Anne K;
- Ewart, Susan;
- Villa, Pia M;
- Moore, Sophie E;
- Willemsen, Gonneke;
- Standaert, Arnout RL;
- Håberg, Siri E;
- Sørensen, Thorkild IA;
- Taylor, Jack A;
- Räikkönen, Katri;
- Yang, Ivana V;
- Kechris, Katerina;
- Nawrot, Tim S;
- Silver, Matt J;
- Gong, Yun Yun;
- Richiardi, Lorenzo;
- Kogevinas, Manolis;
- Litonjua, Augusto A;
- Eskenazi, Brenda;
- Huen, Karen;
- Mbarek, Hamdi;
- Maguire, Rachel L;
- Dwyer, Terence;
- Vrijheid, Martine;
- Bouchard, Luigi;
- Baccarelli, Andrea A;
- Croen, Lisa A;
- Karmaus, Wilfried;
- Anderson, Denise;
- de Vries, Maaike;
- Sebert, Sylvain;
- Kere, Juha;
- Karlsson, Robert;
- Arshad, Syed Hasan;
- Hämäläinen, Esa;
- Routledge, Michael N;
- Boomsma, Dorret I;
- Feinberg, Andrew P;
- Newschaffer, Craig J;
- Govarts, Eva;
- Moisse, Matthieu;
- Fallin, M Daniele;
- Melén, Erik;
- Prentice, Andrew M;
- Kajantie, Eero;
- Almqvist, Catarina;
- Oken, Emily;
- Dabelea, Dana;
- Boezen, H Marike;
- Melton, Phillip E;
- Wright, Rosalind J;
- Koppelman, Gerard H;
- Trevisi, Letizia;
- Hivert, Marie-France;
- Sunyer, Jordi;
- Munthe-Kaas, Monica C;
- Murphy, Susan K;
- Corpeleijn, Eva;
- Wiemels, Joseph;
- Holland, Nina;
- Herceg, Zdenko;
- Binder, Elisabeth B;
- Davey Smith, George;
- Jaddoe, Vincent WV;
- Lie, Rolv T;
- Nystad, Wenche;
- London, Stephanie J;
- Lawlor, Debbie A;
- Relton, Caroline L;
- Snieder, Harold;
- Felix, Janine F
- et al.
Published Web Location
https://doi.org/10.1038/s41467-019-09671-3Abstract
Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10-7). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10-74) and BMI in pregnancy (3/914, p = 1.13x10-3), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth influencing DNA methylation (i.e. reverse causality) requires further research.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
Enter the password to open this PDF file:
-
-
-
-
-
-
-
-
-
-
-
-
-
-