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Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
- Wolpin, Brian M;
- Rizzato, Cosmeri;
- Kraft, Peter;
- Kooperberg, Charles;
- Petersen, Gloria M;
- Wang, Zhaoming;
- Arslan, Alan A;
- Beane-Freeman, Laura;
- Bracci, Paige M;
- Buring, Julie;
- Canzian, Federico;
- Duell, Eric J;
- Gallinger, Steven;
- Giles, Graham G;
- Goodman, Gary E;
- Goodman, Phyllis J;
- Jacobs, Eric J;
- Kamineni, Aruna;
- Klein, Alison P;
- Kolonel, Laurence N;
- Kulke, Matthew H;
- Li, Donghui;
- Malats, Núria;
- Olson, Sara H;
- Risch, Harvey A;
- Sesso, Howard D;
- Visvanathan, Kala;
- White, Emily;
- Zheng, Wei;
- Abnet, Christian C;
- Albanes, Demetrius;
- Andreotti, Gabriella;
- Austin, Melissa A;
- Barfield, Richard;
- Basso, Daniela;
- Berndt, Sonja I;
- Boutron-Ruault, Marie-Christine;
- Brotzman, Michelle;
- Büchler, Markus W;
- Bueno-de-Mesquita, H Bas;
- Bugert, Peter;
- Burdette, Laurie;
- Campa, Daniele;
- Caporaso, Neil E;
- Capurso, Gabriele;
- Chung, Charles;
- Cotterchio, Michelle;
- Costello, Eithne;
- Elena, Joanne;
- Funel, Niccola;
- Gaziano, J Michael;
- Giese, Nathalia A;
- Giovannucci, Edward L;
- Goggins, Michael;
- Gorman, Megan J;
- Gross, Myron;
- Haiman, Christopher A;
- Hassan, Manal;
- Helzlsouer, Kathy J;
- Henderson, Brian E;
- Holly, Elizabeth A;
- Hu, Nan;
- Hunter, David J;
- Innocenti, Federico;
- Jenab, Mazda;
- Kaaks, Rudolf;
- Key, Timothy J;
- Khaw, Kay-Tee;
- Klein, Eric A;
- Kogevinas, Manolis;
- Krogh, Vittorio;
- Kupcinskas, Juozas;
- Kurtz, Robert C;
- LaCroix, Andrea;
- Landi, Maria T;
- Landi, Stefano;
- Le Marchand, Loic;
- Mambrini, Andrea;
- Mannisto, Satu;
- Milne, Roger L;
- Nakamura, Yusuke;
- Oberg, Ann L;
- Owzar, Kouros;
- Patel, Alpa V;
- Peeters, Petra HM;
- Peters, Ulrike;
- Pezzilli, Raffaele;
- Piepoli, Ada;
- Porta, Miquel;
- Real, Francisco X;
- Riboli, Elio;
- Rothman, Nathaniel;
- Scarpa, Aldo;
- Shu, Xiao-Ou;
- Silverman, Debra T;
- Soucek, Pavel;
- Sund, Malin;
- Talar-Wojnarowska, Renata;
- Taylor, Philip R;
- Theodoropoulos, George E;
- Thornquist, Mark;
- Tjønneland, Anne;
- Tobias, Geoffrey S;
- Trichopoulos, Dimitrios;
- Vodicka, Pavel;
- Wactawski-Wende, Jean;
- Wentzensen, Nicolas;
- Wu, Chen;
- Yu, Herbert;
- Yu, Kai;
- Zeleniuch-Jacquotte, Anne;
- Hoover, Robert;
- Hartge, Patricia;
- Fuchs, Charles;
- Chanock, Stephen J;
- Stolzenberg-Solomon, Rachael S;
- Amundadottir, Laufey T
- et al.
Published Web Location
https://doi.org/10.1038/ng.3052Abstract
We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.
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