UC Santa Cruz

This dissertation explores the utilization of internet-connected devices to addressthe accessibility challenges associated with microscopy in the field of biology. Tra- ditional microscopy devices are often costly, limiting their widespread adoption in laboratories. To overcome this barrier, we developed a cost-effective multi-well imaging device integrated with an open-source pump and stimulation system. This device facilitates longitudinal cell studies and reduces the time required for capturing cell images, thereby enhancing efficiency for biologists. Moreover, our internet-connected imaging system serves as an innovative ed- ucational tool for aspiring scientists. Through remote project-based learning ac- tivities and engaging serious games, complex biological concepts become more accessible, fostering enthusiasm and understanding among high school and under- graduate students. The dissertation discusses the application of this system in an educational setting and the implementation of an algorithm for determining organoid size through computer vision. Additionally, it introduces an interactive virtual lab, designed to provide a low-stakes environment for students to learn scientific and laboratory safety protocols. Overall, this work highlights the potential of internet-connected devices in revolutionizing both biological research and education. By making microscopy more accessible and engaging, it empowers scientists and students alike to explore the intricacies of biology with enthusiasm and curiosity.