Skip to main content
VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection
Published Web Location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649228/No data is associated with this publication.
Abstract
We studied the efficacy of the investigational drug VT-1161 against mucormycosis. VT-1161 had more potent in vitro activity against Rhizopus arrhizus var. arrhizus than against R. arrhizus var. delemar. VT-1161 treatment demonstrated dose-dependent plasma drug levels with prolonged survival time and lowered tissue fungal burden in immunosuppressed mice infected with R. arrhizus var. arrhizus and was as effective as high-dose liposomal amphotericin B treatment. These results support further development of VT-1161 against mucormycosis.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.