Glycogen Storage Diseases (GSDs) are genetic disorders of carbohydrate metabolism that can lead to glycogen toxicity in the liver and muscles, as well as severe hypoglycemic episodes, if not properly treated. GSD symptoms and treatment can disrupt daily life, especially in adolescence. Adolescence (ages 10-19) sets the foundation for many psychosocial developmental tasks. GSD can cause social, psychosocial, and biological obstacles to this development and creates a variety of psychosocial challenges in adolescence. This study explores the positive and negative external and internal influences on coping and outlook in adolescents with GSD, and how healthcare professionals, patients, and caregivers might be able to implement early interventions to alleviate some of these burdens. Twelve participants with GSDI or GSDIII participated in semi-structured phone interviews exploring their GSD-related experiences in adolescence. Phronetic iterative analysis was used to analyze transcripts, using the THRIVE model as a guide for organizing themes related to psychosocial challenges (or coping) during adolescence and the role of healthcare providers in this process. Themes and subthemes that emerged include the positive and negative effects of: Therapeutic Interventions (finding dedicated healthcare providers, facing difficulty in the healthcare system), Habits and Behavioral Factors (acceptance/consistency in routine, having typical childhood/adolescent experiences, gaining/desiring independence with treatment management, having incentives/goals, not complying with treatment/diet), Relational/Social Factors (feeling advocated for/supported by others, sharing GSD with everyone vs. not sharing GSD with anyone, being bullied, difficulty connecting with others, being isolated/excluded, feeling singled out/like an outsider), Individual Differences (forming identity/personality, experiencing negative symptoms, Values and Beliefs (accepting condition over time, having a "things could be worse" attitude, negative thoughts about one's body, feeling different than peers), and Emotional Factors (having open communication with parents/providers, feeling fearful, experiencing mental fatigue, internalizing symptoms). In conclusion, open communication between patients, caregivers, and healthcare providers will provide avenues to promote early intervention of and address many of the obstacles faced in adolescence by individuals with GSD.