Recent ucd_ome_posters_pediatrics items

Poor glycemic control is associated with pro-inflammatory CXCL10 elevation in children and adolescents with established type 1 diabetes

Thu, 17 Jul 2025 00:00:00 +0000

Poor glycemic control is associated with pro-inflammatory CXCL10 elevation in children and adolescents with established type 1 diabetes

Using targeted client communication via mobile devices (TCCMD) to promote exclusive breastfeeding (EBF) in Roatán, Honduras

Wed, 25 Jun 2025 00:00:00 +0000

Exclusive breastfeeding (EBF) for 6 months provides significant benefits, including decreased incidence of respiratory and GI infections. Promoting EBF is a cost-effective method to improve infant health and survival. Roatán is a Honduran island where infant mortality is more than triple the country’s average. Data on infant feeding practices and EBF prevalence in Roatan is limited.

ACS Children’s Surgery Center Verification Improves Efficiency and Decreases Narcotic Administration in Treating Pediatric Trauma Patients

Wed, 25 Jun 2025 00:00:00 +0000

Purpose of Study: In 2015, the American College of Surgeons (ACS) created a new hospital designation to improve the efficiency and performance of care for children in American Children’s Hospitals. The Children’s Surgery Center (CSC) verification is achieved when a hospital system demonstrates excellence in its infrastructure and in its operations toward the pediatric-specific care of patients. Several important elements include 24-hour, 7-day a week availability of Pediatric surgical subspecialties, Pediatric Nursing, and Pediatric Anesthesia teams, access to pediatric beds, quality improvement programs, and hospital quality enhancements. Efficient care of pediatric femur fractures is representative of the highest level of care for pediatric trauma patients. The study was performed at one of six ACS pilot sites for the ACS CSC verification, to determine the designation’s effect in improving the efficiency of managing orthopaedic trauma patients.

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Pediatric Asthma: UC Davis Participation in a Global Network Study

Wed, 25 Jun 2025 00:00:00 +0000
Pediatric Asthma: UC Davis Participation in a Global Network Study

Pediatric Rapid Response Team Quality Improvement Initiative – Preliminary Findings

Thu, 5 Dec 2024 00:00:00 +0000
Background: Rapid Response Teams are activated in non-critical care settings to provide or expedite access to escalated care before patient condition rapidly deteriorates. Patients who undergo cardiopulmonary arrest may experience emergency “Code Blue” activation. However, in clinical situations where a patient’s condition is concerning but not yet deteriorating, an intermediary Rapid Response Team (RRT) may be activated to facilitate early detection and management of at-risk patients. Pediatric Rapid response team implementation is associated with “reduction in hospital-wide mortality rate and code rate outside of the pediatric ICU”. UC Davis Medical Center has had preexisting RRTs, but prior to Fall 2020 did not have a pediatricspecific RRT for its Children’s Hospital. UCDMC is unique in that it is one of few major academic medical centers that does not have structural separation between the children- and adult-side of the hospital, and are instead housed within...

A novel model of pediatric glioma of H3F3A mutant and TP53 mutant cerebral organoids

Thu, 5 Dec 2024 00:00:00 +0000
A novel model of pediatric glioma of H3F3A mutant and TP53 mutant cerebral organoids

PROMIS Scores for Children with Unilateral Congenital Below Elbow Deficiency (UCBED)

Thu, 5 Dec 2024 00:00:00 +0000

• Patients with unilateral congenital below elbow deficiency (UCBED) are born with a unilateral transverse deficiency at the level of the forearm.
• Based on previous studies, these patients have been shown to have milder than expected disability and their impairment is not reduced by using a prosthesis.
• This work resulted in changes in practice regarding prosthetic prescription for children with UCBED. However, it did not address the social stigma caused by this impairment, nor did it provide actionable information to improve the functional deficits that these children experience.
• Although PROMIS discerns UE function in other congenital arm differences, results for children with UCBED are not known.
• This study evaluates their responses to PROMIS Short Form Upper Extremity Function (UEF), Mobility, and Peer Relationships (PR) domains.

Short-term Outcomes of Therapeutic Hypothermia through Veno-Arterial Extra Corporeal Membrane Oxygenation for HIE and Severe PPHN

Thu, 5 Dec 2024 00:00:00 +0000
Short-term Outcomes of Therapeutic Hypothermia through Veno-Arterial Extra Corporeal Membrane Oxygenation for HIE and Severe PPHN

Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Use in Pediatric Populations

Mon, 18 Nov 2024 00:00:00 +0000
Children undergoing microdirect laryngoscopy and bronchoscopy (MDLB) pose anesthetic challenges while providing a motionless surgical field without an endotracheal tube.

Beware the Transverse Plane: Variability of “Normal Gait” In Typically Developing Children

Mon, 18 Nov 2024 00:00:00 +0000

1. Quantify stride-to-stride variability in typically developing (TD) children using three-dimensional gait analysis (3DGA) in an expanded set of 14 kinematic variables.
2. Assess the effect of laterality, age, and sex on stride-to-stride variability

Adverse Childhood Experiences and Developmental Delay in Young US Children

Tue, 12 Nov 2024 00:00:00 +0000

Purpose of Study: Adverse childhood experiences (ACEs) have been associated with developmental delay and poor health outcomes in late childhood and adolescence. Health promoting practices such as breastfeeding and daily reading have been associated with lower rates of developmental delay. This study aims to investigate the association between early ACE exposure, protective health behaviors, and the diagnosis of developmental delay in early childhood.
Methods Used: In this cross-sectional analysis of population-representative date from the 2017-2018 National Survey of Children’s Health, we examined the relationship between ACEs, prior breastfeeding, daily reading, and diagnosis of developmental delay among 7837 children aged 3-5 years, using multivariate logistic regression to adjust for family, personal (i.e. premature birth, or low birth weight), and sociodemographic characteristics.
Summary of Results: We found...

Effect of Isotretinoin on Adolescent Growth: a retrospective chart review

Thu, 7 Nov 2024 00:00:00 +0000

• Isotretinoin (13-cis-retinoic acid) is a retinoid or vitamin A derivative widely used to treat severe acne vulgaris.
• Decreases sebum production and prevents comedo formation.
• Isotretinoin use is associated with a variety of toxicities: developmental, cutaneous, musculoskeletal, etc.
• including hyperosteosis and premature epiphyseal closure at high doses.
• No studies examining pediatric growth in patients treated with isotretinoin at doses appropriate for severe, recalcitrant acne vulgaris treatment.

Obstacles to Breastfeeding in Inpatient Pediatric Settings

Thu, 7 Nov 2024 00:00:00 +0000
Breastfeeding is the optimal source of infant nutrition and is important for both infant and maternal health. The Ten Steps to Successful Breastfeeding, which are recommended by the World Health Organization (WHO) and endorsed by the American Academy of Pediatrics (AAP) and form the basis of the Baby-Friendly Hospital Initiative, recommend showing parents how to maintain lactation, even if they are separated from their infants. However, hospital policies regarding inpatient breastfeeding support outside the postpartum period are lacking. Length of hospitalization has been correlated with parents’ decisions to discontinue breastfeeding post-hospitalization. The increased incidence of weaning following an infant’s hospitalization indicates potentially modifiable factors to prolong breastfeeding duration. Therefore, it is prudent to understand breastfeeding parents’ experiences regarding breastfeeding support and challenges in an inpatient hospital setting.

Literacy Promotion in the Well Newborn Nursery

Mon, 4 Nov 2024 00:00:00 +0000

The AAP recommends beginning shared reading at birth as it promotes optimal infant development and parent-child interactions.
Limited data exists on best practices around shared reading promotion in infants 0-6 months.

A novel model of pediatric glioma of H3F3A mutant and TP53 mutant cerebral organoids

Wed, 30 Oct 2024 00:00:00 +0000

Diffuse Intrinsic Pontine Glioma (DIPG) is an incurable childhood brainstem tumor, affecting 200-400 children in the United States per year. Once diagnosed, the only known treatment is radiation, with death occurring in <12 months of initial diagnosis.
Resection is impossible due to its location and infiltrative growth. Chemotherapeutic agents are ineffective due to poor understanding of underlying molecular and cellular biology, and lack of in-vitro and in-vivo models for testing.
In patients with DIPG, genetic mutations of gain-of-function K27M of Histone H3.3 gene (H3F3A) and loss-of-function P53 gene (TP53) frequently co-occur.

A Novel Classification System for Patients with Persistent ITW

Tue, 29 Oct 2024 00:00:00 +0000

By the age of 3, most children develop a mature gait pattern, defined as plantigrade use of the foot with weightbearing through both the heel and metatarsal heads.
Children with idiopathic toewalking (ITW) are otherwise neurologically normal but preferentially walk on their tiptoes. ITW resolves in most cases by 6 years of age.
Children with persistent ITW (ITWp) may develop ankle contractures and foot skeletal deformities.
The Alvarez criteria was established in 2006 and has since been the standard classification for ITWp based

Use of Transcutaneous Carbon Dioxide Monitors (TCOMs) in the NICU

Tue, 29 Oct 2024 00:00:00 +0000

Neonates on respiratory support often experience rapid changes in their carbon dioxide (CO2). These fluctuations in CO2 concentrations can alter cerebral blood flow and increase the risk of intraventricular hemorrhage.
Frequent blood sampling to monitor CO2:
• Disrupts sleep - wake cycle
• Is painful; associated with chronic pain
• Associated with poor developmental outcomes
Transcutaneous carbon dioxide monitors (TCOMs) allow for measurement of the partial pressure of carbon dioxide (pCO2). This technology utilizes the diffusion properties of CO2 through tissues and skin, allowing for sensor readings at the skin surface. Using this technology available, newborns in the NICU will not have to endure as many blood draws and will lower risks of complications.

Phase I Study of Escalating Doses of Carfilzomib with Hyper-CVAD in Patients with Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma

Tue, 29 Oct 2024 00:00:00 +0000

• Hyperfractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone (Hyper-CVAD) results in high complete remission (CR) rates, long-term survival in 30-40%1 , and measurable/minimal residual disease (MRD) negativity in 50% adults with acute lymphoblastic leukemia (ALL).
• Proteasome inhibitors have synergistic activity with chemotherapy in relapsed ALL.
• Carfilzomib, a next-generation irreversible and selective inhibitor of the chymotrypsin-like activity of the proteasome, shows increased specificity, potency, and cellular apoptotic sensitivity compared to bortezomib in ALL.
• Carfilzomib shows preclinical activity in ALL ex vivo studies, and has promising synergism with dexamethasone.
• We hypothesized that adding carfilzomib to Hyper-CVAD would be safe and could better outcomes in adults with ALL.

Utility of Routine Head Ultrasounds in Screening for Intracranial Hemorrhage in Infants on Extracorporeal Life Support

Wed, 23 Oct 2024 00:00:00 +0000
Intracranial hemorrhage (ICH) is a devastating complication of extracorporeal life support (ECLS), but the only studies on the timing of ICH detection by head ultrasound (HUS) in infants is from two decades ago. In light of advancements in imaging technology and neonatal and pediatric critical care, our objectives were to provide updated data on the timing of ICH in infants on ECLS and to identify risk factors associated with ICH.

Utilization of Telehealth for Inpatient Pediatrics in the Post-COVID Era

Tue, 22 Oct 2024 00:00:00 +0000
Telehealth has been utilized to provide convenient and effective care in the outpatient setting and emergency consultations for outside hospitals. In the setting of the COVID-19 pandemic many hospitals rapidly expanded telemedicine usage to incorporate inpatient pediatric care in order to reduce the risk of transmission. While hospitals rapidly expanded their use of telehealth throughout inpatient care, it remains unknown how the use of inpatient telehealth will continue moving forward post-pandemic. After nearly a year of incorporation in this setting, we are now capable of establishing a better idea of the benefits and limitations of telemedicine for inpatient pediatrics. For this study, we conducted a single-site qualitative interview guide based on questions that focused on 3 major topics: (1) use of inpatient telehealth during COVID-19, (2) potential uses of inpatient telehealth after COVID-19, (3) and strategies to optimize inpatient telehealth after COVID-19. Interviews...

Expansion of the Pediatric Cardiac Interventional Repertoire – Renal Artery Interventions

Wed, 16 Oct 2024 00:00:00 +0000
Adult interventional cardiologists have expanded their procedural repertoire to include renal artery interventions, while the pediatric cardiology community has not yet followed suit. There is little data originating from pediatric cardiologists on catheterization and intervention to treat renal artery stenosis in pediatric patients

Quantitative Assessment of Pediatric Joint Contributions to Foot Clearance and Dynamic Leg Length

Wed, 16 Oct 2024 00:00:00 +0000
It has been noted that tripping and falling are the greatest source of accidental injury in children with motor disabilities[1]. Tripping most commonly occurs due to a decrease in foot clearance or ineffective limb shortening during the swing phase of gait. Moosabhoy and Gard developed equations based on a planar model of the leg to look directly at joint contributions to foot clearance in the adult population (Fig. 1)[2]. We modified and applied the analytical techniques used by Moosabhoy and Gard to analyze a new population of patients.

10-year Follow-Up for Sequalae In Pediatric Burn Survivors

Wed, 16 Oct 2024 00:00:00 +0000
The purpose of this study is to examine the long-term physical and psychosocial sequelae of pediatric burns on the surviving patients.

ACCURACY OF TRANSCUTANEOUS CO2(TCO2) MONITORING IN NEWBORNS UNDERGOING THERAPEUTIC HYPOTHERMIA

Wed, 16 Oct 2024 00:00:00 +0000
Therapeutic hypothermia (TH) is standard of care in the management of hypoxic-ischemic encephalopathy (HIE). Fluctuations in partial pressure of arterial carbon dioxide (PaCO2) during TH is associated with poor neurodevelopmental outcomes. Frequent arterial blood gas monitoring may not be practical. Study the accuracy of transcutaneous CO2 (TCO2) in newborns undergoing TH

The impact of direct-to-home telemedicine visits on parent, physician, and therapist experience for children with special healthcare needs

Wed, 16 Oct 2024 00:00:00 +0000
To examine the experience of parents, therapists, and physiatrists on direct-to-home tele-physiatry visits with the goal of informing future use of telemedicine for children with special healthcare needs.

Two Pediatric Cases of Amebic Meningoencephalitis

Wed, 16 Oct 2024 00:00:00 +0000
• We suspect that our first patient’s presentation with discolored and foul-smelling urine may reflect amebic spread to the urinary tract • Our case of B. mandrillaris had the expected CSF abnormalities for amebic encephalitis • Lymphocytic pleocytosis • Elevated protein (peaked at 913 mg/dl) • Persistent hypoglycorrhachia • Our case of N. fowleri did not have characteristic CSF findings • Glucose remained normal • Typically, N. fowleri presents with a lower CSF glucose than B. mandrillaris – our cases show the opposite findings

Newborn Abdominal Massage to Prevent Hyperbilirubinemia: A Pilot Randomized Controlled Trial

Wed, 16 Oct 2024 00:00:00 +0000
To determine the acceptability of newborn massage intervention and its feasibility. To determine the extent to which a structured newborn abdominal massage can affect infant bilirubin excretion and lower bilirubin level away from the AAP hour-specific phototherapy treatment threshold

A Novel Scoring Tool for Neonatal Persistent Pulmonary Hypertension

Wed, 16 Oct 2024 00:00:00 +0000
At birth, a decrease in pulmonary vascular resistance (PVR) is essential to facilitate pulmonary vascular perfusion as the infant establishes independent use of the lungs. • When PVR fails to decrease, hypoxemic respiratory failure (HRF) and pulmonary hypertension (PH) ensues. • A novel scoring tool was developed to characterize severity of HRF and PH in the setting of a critically ill newborn, accounting for level of hypoxemia and echocardiographic findings of PH.At birth, a decrease in pulmonary vascular resistance (PVR) is essential to facilitate pulmonary vascular perfusion as the infant establishes independent use of the lungs. • When PVR fails to decrease, hypoxemic respiratory failure (HRF) and pulmonary hypertension (PH) ensues. • A novel scoring tool was developed to characterize severity of HRF and PH in the setting of a critically ill newborn, accounting for level of hypoxemia and echocardiographic findings of PH.

Is it Possible to Grow B-ALL Primary Leukemia Cells In Vitro?

Wed, 16 Oct 2024 00:00:00 +0000
B-ALL is the most common cancer in children, but B-ALL primary leukemia cells are not known to grow well in vitro (1,2). In vitro cell culture is a valuable tool used to craft therapies and run other studies without using in vivo models. Currently, Dr. Satake’s lab has been working with B-ALL in xenograft models. Serum-free culture conditions, including those similar to hematopoietic progenitor cell media, have been used to proliferate ALL blasts previously (with FLT3, SCF, and IL3 growth factors) (3). Unfortunately, outside of co-culture with mesenchymal stem cells (MSCs), there is a “lack of suitable in vitro culture conditions” to culture primary B-ALL cells (2). Therefore, we will attempt to use hematopoietic stem cell (HSC) media to attempt to culture primary B-ALL cells.

The association between juvenile xanthogranulomas in neurofibromatosis type 1 patients and the development of leukemia: A systematic review

Wed, 16 Oct 2024 00:00:00 +0000
Neurofibromatosis type 1 (NF1) is an inherited tumor syndrome caused by heterozygous germline mutations in the NF1 gene, occurring in approximately 1/2600 individuals. A subset of patients with neurofibromatosis type 1 (NF1) develop juvenile xanthogranulomas (JXGs), a non-Langerhans cell histiocytosis, and some of these patients also develop juvenile myelomonocytic leukemia (JMML).Yet, these associations are poorly delineated.JXG is a benign proliferation of non-Langerhans cells histiocytes characterized by small yellow/brown papulonodules ranging from 1-20 mm in size. JMML is a mixed myeloproliferative-myelodysplastic disorder that affects children, most often before age 6.4. The first and only systematic review on this described therisk of developing JMML 20 to 30 times higher in patients with NF1 with JXG lesions compared to those without JXG. Since then, mostly isolated case reports have either refuted or confirmed this triple association.

Enhancing Patient Safety in the Pediatric Emergency Department through Simulation

Fri, 11 Oct 2024 00:00:00 +0000

• Patient safety hazards and adverse events are a significant concern in the United States, especially in the pediatric population
• Approximately 13 adverse events occur per 1,000 hospital discharges for children
• Increasing situational awareness is an effective intervention to enhance patient safety
• Learning how to report identified errors and near misses enables mitigation of real or possible harm
• Simulation helps learners and trainees develop situational awareness
• Patient care simulation scenarios have demonstrated improvements in learner confidence and their ability to identify safety hazards

Reliability and Utility of a Novel Classification Scheme for Gait Deviations in Children with Persistent Idiopathic Toe Walking

Fri, 11 Oct 2024 00:00:00 +0000
Neurotypically developing children who toe walk usually spontaneously resolve by school age, those who do not are considered to have Persistent Idiopathic Toe Walking (ITWp) and may develop ankle contractures and foot skeletal deformities. Alvarez et al. proposed a classification scheme in 2006. When it was applied to our cohort, it failed to classify many subjects due to ambiguity in the classification scheme definitions

Socioeconomic Disparities in Pediatric Scoliosis Surgery

Fri, 11 Oct 2024 00:00:00 +0000
Multiple studies have been published which investigate the effects of patient demographics on elective orthopedic operations. While this research demonstrates disparities in health care delivery in other states and in single center practices, there are large administrative databases that can be used to examine patient demographics and their influence on health care delivery. We queried the State of California Office of Statewide Health Planning and Development (OSHPD) database to compare the proportions of patients undergoing surgery for scoliosis by gender, race, and ethnicity and to determine if there were underlying differences in social determinants of health as measured by the child opportunity index (COI), social deprivation index (SDI), and insurance type among these patients in order to create a foundation of knowledge for future research on health disparities in the realm of orthopaedic surgery.

Outcomes in Pediatric Glaucoma

Fri, 11 Oct 2024 00:00:00 +0000

• Pediatric Glaucoma is a heterogeneous group of disorders with unique management challenges, namely an uncommon occurrence, with restricted evaluation techniques, and young patients.
• Challenges faced in treatment plans:
• Young eyes are more sensitive so elevated IOP can cause structural changes to the eye (e.g. buphthalmos)
• Etiology of vision impairment is multifactorial
• Previously studied risk factors for visual impairment are unilateral disease, multiple surgeries, poor vision at diagnosis, and other ocular comorbidities.
• Chang et. al (2018) conducted a pilot study of 15 pediatric patients and examined the impact of certain predictive factors on long-term visual acuity and IOPcontrol outcomes and creating a severity scale.

Can Home ECG Monitoring Be Used to Evaluate Heart Rate Variability in Infants with Congenital Heart Disease?

Thu, 10 Oct 2024 00:00:00 +0000
Reduced heart rate variability (HRV), an indicator of autonomic nervous system dysfunction, can be used to identify critically ill patients at higher risk for adverse outcomes. Limited data exists on HRV in children with cardiac disease. Early detection of reduced HRV with home monitoring systems may lead to improved outcomes in high-risk infants with complex congenital heart disease.

Can Home ECG Monitoring Be Used to Evaluate Heart Rate Variability in Infantswith Congenital Heart Disease?

Tue, 17 Sep 2024 00:00:00 +0000
Reduced heart rate variability (HRV), anindicator of autonomic nervous systemdysfunction, can be used to identify critically ill patients at higher risk for adverse outcomes.Limited data exists on HRV in children withcardiac disease. Early detection of reduced HRV with home monitoring systems may lead to improved outcomes in high-risk infants withcomplex congenital heart disease. Home ECG monitoring is a valid method to obtain HRV data.

Socioeconomic Disparities in Pediatric Scoliosis Surgery

Tue, 17 Sep 2024 00:00:00 +0000
Socioeconomic Disparities in Pediatric Scoliosis Surgery

Can Home ECG Monitoring Be Used to Evaluate Heart Rate Variability in Infants with Congenital Heart Disease?

Tue, 10 Sep 2024 00:00:00 +0000
Reduced heart rate variability (HRV), anindicator of autonomic nervous systemdysfunction, can be used to identify critically ill patients at higher risk for adverse outcomes.Limited data exists on HRV in children withcardiac disease. Early detection of reduced HRV with home monitoring systems may lead to improved outcomes in high-risk infants withcomplex congenital heart disease. Home ECG monitoring is a valid method to obtain HRV data.

In Vitro Support of Primary Leukemia Cells

Tue, 3 Sep 2024 00:00:00 +0000
No in vitro method for culturing Primary Leukemia Cells exists. Thus, study of Primary Leukemia biology requires immunodeficient mouse models, which is costly and time consuming. Identifying a method to grow and maintain Primary Leukemia Cells in vitro would allow biological and molecular assays to facilitate bench to bedside translation.

Amiloride Derivative Compound 10357 in the Treatment of B-Cell Acute Lymphoblastic Leukemia

Fri, 30 Aug 2024 00:00:00 +0000
Compound 10357 is an amiloride derivative with potential promise as an adjunct to current chemotherapeutics. This study investigates the therapeutic efficacy of Compound 10357 in B-Cell Acute Lymphoblastic Leukemia (B-ALL).

Pediatric Rapid Response Team Implementation and Outcomes in a Children’s Hospital within a Mixed Academic Health Center

Thu, 29 Aug 2024 00:00:00 +0000
Rapid Response Teams (RRTs) are teamsof healthcare providers called to patient bedside for unexpected or sudden changes inpatient conditions. Such teams are intended to intervene before patients experience Sudden Adverse Events (SAEs) or require ‘code blue’ activation. Markers such as abnormal vital signs raise concern for providers and patient families as these acute changes may precedecardiopulmonary arrest (CPA).2 A mechanismof activation to urgently introduce additional providers to bedside allows for patients to be seen before patient deterioration. A systematic review noted that “rapid response systems were associated with a reduction in hospital mortality and cardiopulmonary arrest.”

Diagnostic Challenges of Fever of Unknown Origin Case Report of a Rare Hepatic Abscess in a 2-year-old

Thu, 29 Aug 2024 00:00:00 +0000
Atypical presentations of conditions make identifying source of Fever of Unknown Origin (FUO) challenging. Incidence of hepatic abscesses (HA) in the pediatric population in the U.S. is 25 per 100,000 admissions. Most cases occur in children with predisposing factors such as appendicitis or immunocompromised state.

HANDFULS: Hand Accumulation and Dexterity Functional Limits – Shriners Normal Hand Function Study

Thu, 29 Aug 2024 00:00:00 +0000
Clinicians routinely measure hand function in patients following hand injury or surgery. Hand function is assessed through patient-reportedoutcome measures (PROMs) or clinical tests and measurements of grip strength, dexterity, and range of motion. Several available tests measure these components of hand function; however, few tests comprehensively measure in-hand collection and manipulation and handvolume. For this reason, we developed a novel test to assess hand volume and in-hand collection and manipulation using marbles.

Deriving a Rule for Termination of Resuscitation in Pediatric Out-of-Hospital Cardiac Arrest

Thu, 29 Aug 2024 00:00:00 +0000
Pediatric out-of-hospital cardiac arrest (OHCA) is an uncommon and stressful situation for providers. Despite advanced life support interventions and optimal resuscitationtechniques, pediatric OHCA carries a low survival rate of 11.3%. Accepted criteria exist for adult patients, but not children. There is a need to develop criteria to guide termination ofresuscitation in cases when continued care would be futile.

Newborn Abdominal Massage to Prevent Hyperbilirubinemia – a Feasible Trial at UCDMC?

Wed, 28 Aug 2024 00:00:00 +0000
Hyperbilirubinemia in newborns can lead to significant neurological complications including hearing loss, cerebral palsy, and gazeabnormalities. 5-10% of infants born ≥35 weeks have hyperbilirubinemia requiringphototherapy. Phototherapy often requireslonger inpatient stays or rehospitalization. Phototherapy also associated with decreased early breastfeeding and increased risk of childhood cancer and seizures.

Understanding pediatric readiness in community emergency departments in Northern California: a mixed methods study

Wed, 28 Aug 2024 00:00:00 +0000
Access to pediatric emergency care is oftenlacking for children living in rural andunderserved communities. Hospitals in ruralcommunities are generally less preparedto handle pediatric emergencies. Training and resources were provided to community ED providers through a 7-year UC Davis program(TACTICAL).

Outcomes with Hepatitis B Co-Infection in Pediatric Renal Transplant Recipients

Wed, 28 Aug 2024 00:00:00 +0000
Investigate if various HBV serostatus markers are associated with differences in graft survival in pediatric renal transplant recipients.

Pediatric Magnet Ingestion Remains A Significant Cause of Morbidity Despite Increasing Regulations Worldwide

Wed, 28 Aug 2024 00:00:00 +0000
Pediatric magnet ingestion can lead to devastating consequences, such as bowel obstruction, ischemia, intestinal erosion, and intestinal fistulas. This study sets out to investigate and compare the global incidence of pediatric magnet ingestion and corresponding national policies.

Infant Feeding Practices and Parental Perceptions During the 2022 United States Infant Formula Shortage Crisis

Wed, 28 Aug 2024 00:00:00 +0000
In May of 2022, parents living in the United States (U.S.) experienced a significant infant formula shortage with national out-of-stock rates of up to 74% for the week ending in May 28, 2022. Longstanding Contributing Factors:few U.S. formula producers, U.S. trade policy and high tariff rates, Infant formula rebate contracts used by the Special Supplemental Nutrition Program for Woman Infant Children(WIC).

Trajectory Of Project Baby Bear Rapid Genome Sequencing Project: A Review of Long-Term Follow Up at a Single Center

Tue, 27 Aug 2024 00:00:00 +0000
Project Baby Bear was a prospective quality improvement project which demonstrated the clinical utility and economic impact of ultrarapid or rapid whole genome sequencing (rWGS) in neonatal and pediatric intensive care units for Medi-Cal beneficiaries. This study found that rWGS provided a diagnosis for 40% of the patients and changed medical care for 32% of them. However, there is limited information on the long-term clinical outcomes and follow up of these individuals.

Predictors of Cartilage Injury in Pediatric Patellar Instability Remain Unknown

Tue, 27 Aug 2024 00:00:00 +0000

Pediatric patellofemoral instability, most commonly lateral patellar dislocation, can result in cartilageinjury (chondral or osteochondral fracture) to the knee.
Specific anatomical characteristics can predict the severity of patellar instability • Can we identify anatomical predictors of cartilage injury in patients with patellar instability?

Psychosocial Support for Pediatric Victims of Gun Violence

Tue, 27 Aug 2024 00:00:00 +0000
Psychosocial support is an important piece of the recovery for pediatric gunshot victims. We wanted to see how many of our pediatric patients who are victims of gun violence have had psychosocial issues and how many received psychosocial support.

Prenatal Methamphetamine Exposure: Short-term Neonatal Outcomes

Tue, 27 Aug 2024 00:00:00 +0000
Methamphetamine use has been increasing across the country, including among persons of childbearing agePrenatal exposure to methamphetamine has been associated with growth restriction in infants.

Decreasing Radiation Exposure in Children Who Need Cervical Spine Clearance After TBI

Tue, 27 Aug 2024 00:00:00 +0000
Pediatric cervical spine injury (PCSI) can result in devastating neurologic disability. Prompt and accurate diagnosis of PCSI is an essential component of trauma care (1). While computed tomography (CT) imaging is both sensitive and specific in detecting clinically significant injuries, indiscriminate utilization can lead to unnecessary ionizing radiation exposure. During a routine trauma audit process in 2019, we observed a high CT utilization rate of 54%, and CT’s were appropriately obtained only 46% of the time. In response, and in conjunction with newer published guidelines (2), we updated our institutional PCSI protocol. The updated protocol was developed in a consensus-based process among trauma stakeholders and came into effect February 2022.

Differentiation of Neuroblastoma Cells: Can MicroRNAs be Used as a Therapeutic? A Systematic Review

Tue, 27 Aug 2024 00:00:00 +0000
Study Aim: To determine which miRs promote NB cell differentiation and through what mechanisms

The Long-term Characterization of Behavior Phenotypes in Children with Seizures over 36 months

Tue, 27 Aug 2024 00:00:00 +0000
Previous studies have documented that children with newly diagnosed epilepsy often exhibit various behavioral comorbidities such as anxiety, depression, aggressive behavior, and attention that affect many aspects of their life including academic performance. Furthermore, these studies have identified distinct behavioral phenotype groups but have not investigated the trajectory of each of these groups over time. In this study we explore the presence and trajectory of behavior and academic performance in children with newly diagnosed epilepsy and their siblings over a 36-month period.

Developing a Pediatric CAR T-cell Comorbidity Index: Evaluationof Pre-existing Models in Pediatric B-ALL Patients

Tue, 27 Aug 2024 00:00:00 +0000

1. Test existing adult-validated predictive models of CAR associatedtoxicities in pediatric patients with B-ALL including the M-EASIX and CAR-HEMATOTOX model.
2. To determine if the M-EASIX and CAR-HEMATOTOX model can predict post-CAR outcomes including:• CRS and CRS Maximum Grade• ICANS and ICANS Maximum Grade

Assessing Guideline Implementation for Community-Acquired Pneumonia (CAP) at UC Davis Children's Hospital

Tue, 27 Aug 2024 00:00:00 +0000
We aim to assess implementation of our revisedinstitutional guidelines pertaining to:(1) Initial empiric antibiotic givenAmpicillin/amoxicillin are first-line for healthy, fullyimmunizedchild; use of broad-spectrum antibiotic isdependent on various factors (Table 3)(2) Time to antibiotic de-escalationAppropriate de-escalation from a broad- to narrowspectrumantibiotic is ≤72 hours(3) Total antibiotic durationAppropriate duration of antibiotic therapy is 5-7 days

Impact of Literacy Advocacy Among Low-Income, Firstborn Infants in the Newborn Nursery: A Pilot Randomized Control Study

Tue, 27 Aug 2024 00:00:00 +0000
Reach Out and Read (ROR) program is an evidence-based method for incorporating literacy education into pediatric visits and teaching parents the importance of reading aloud, starting at the 6 month well child visit 1 Studies of the effect of encouraging reading during the birth hospitalization on shared reading behaviors are limited.

Heptelidic acid displays cytotoxicity against rhabdoid tumor of the kidney in vitro

Tue, 27 Aug 2024 00:00:00 +0000
Rhabdoid tumor of the kidney (RTK) is a rare but aggressive cancer that occurs in infancy and early childhood.[1] Current treatment protocols for RTK included a combination of surgery, radiation therapy, and chemotherapy, however the prognosis remains poor with a 5-year survival between 20-25%.[1] Therefore, the need to develop therapeutic strategies to treat RTK is still greatly unmet. High dependence on glycolysis by cancer cells, known as the Warburg effect [2], demonstrates a weakness that can be harnessed to target cancer cells and provides rationale for exploring antiglycolytic approaches for targeting cancer cells. Glyceraldehye-3-phosphate dehydrogenase (GAPDH) is an essential enzyme within the glycolysis pathway (Figure 1) making GAPDH a potential therapeutic target for inhibiting tumor growth and progression [3]. Aspergillus oryzae is a probiotic fungus that is used in the production of Japanese fermented food, including soybean paste and soy sauce. Heptelidic acid (HA)...

Case Series of Vestibular Migraine in Fragile X Premutation Carriers

Tue, 27 Aug 2024 00:00:00 +0000
This case series plus review seeks to describe the clinical characteristics and pathophysiology of VM among individuals with the fragile X premutation. We also seek to discuss treatment and future steps in addressing VM in this population.

Transition to adulthood for youth with neurodevelopment disorders- family/caregiver survey and needs assessment

Tue, 27 Aug 2024 00:00:00 +0000
Transition to adulthood is a challenging process that is especially difficult for youth with neurodevelopmental disorders (NDD) and their caregivers. Due to transition age youth with NDD having complex medical and behavioral health needs, youth and their caregivershave to navigate several systems of care to support them. Despite these challenges, there has been limited research into the needs of this population during transition to adulthood from a quality improvement perspective.